Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

摘要

BackgroundBased on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (>7), with IC50 value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this research are design and synthesis of >7 and other chalcone derivatives by Claisen–Schmidt condensation and then evaluate their XO inhibitory activity.