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Pulmonary rehabilitation improves survival in patients with idiopathic pulmonary fibrosis undergoing lung transplantation

机译:肺康复可改善特发性肺纤维化患者接受肺移植的存活率

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摘要

This study was conducted to evaluate whether a pulmonary rehabilitation program (PRP) is independently associated with survival in patients with idiopathic pulmonary fibrosis (IPF) undergoing lung transplant (LTx). This quasi-experimental study included 89 patients who underwent LTx due to IPF. Thirty-two completed all 36 sessions in a PRP while on the waiting list for LTx (PRP group), and 53 completed fewer than 36 sessions (controls). Survival after LTx was the main outcome; invasive mechanical ventilation (IMV), length of stay (LOS) in intensive care unit (ICU) and in hospital were secondary outcomes. Kaplan-Meier curves and Cox regression models were used in survival analyses. Cox regression models showed that the PRP group had a reduced 54.0% (hazard ratio = 0.464, 95% confidence interval 0.222–0.970, p = 0.041) risk of death. A lower number of patients in the PRP group required IMV for more than 24 hours after LTx (9.0% vs. 41.6% p = 0.001). This group also spent a mean of 5 days less in the ICU (p = 0.004) and 5 days less in hospital (p = 0.046). In conclusion, PRP PRP completion halved the risk of cumulative mortality in patients with IPF undergoing unilateral LTx
机译:进行这项研究的目的是评估接受肺移植(LTx)的特发性肺纤维化(IPF)患者的肺康复计划(PRP)是否与生存独立相关。这项准实验研究纳入了89位因IPF而接受LTx的患者。在等待LTx(PRP组)的列表中,有32个完成了PRP中的所有36个会话,并且有53个完成了少于36个会话(控件)。 LTx后的生存是主要结局。次要结果是有创机械通气(IMV),重症监护病房(ICU)和住院时间(LOS)。 Kaplan-Meier曲线和Cox回归模型用于生存分析。 Cox回归模型显示,PRP组的死亡风险降低了54.0%(危险比= 0.464,95%置信区间0.222-0.970,p = 0.041)。 PRP组中较少的患者在LTx后需要IMV持续24小时以上(9.0%比41.6%,p = 0.001)。该组在ICU上的平均花费减少了5天(p = 0.004),在医院的平均减少了5天(p = 0.046)。总之,PRP PRP完成使接受单侧LTx的IPF患者的累积死亡率风险减半

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