Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor Neuronal and Astrocyte Apoptosis Gliosis and Deterioration of Postsynaptic Density

摘要

BackgroundAdult hypothyroidism is a highly prevalent condition that impairs processes, such as learning and memory. Even though tetra-iodothyronine (T4) treatment can overcome the hypothyroidism in the majority of cases, it cannot fully recover the patient's learning capacity and memory. In this work, we analyzed the cellular and molecular changes in the adult brain occurring with the development of experimental hypothyroidism.