Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model

摘要

This study demonstrates that the use of multispectral optoacoustic tomography (MSOT) to detect the intrinsic signal unmixed for melanin enables detection of melanoma micrometastases and in-transit metastases in a B16F10 mouse model and that this ability is superior to that with fluorodeoxyglucose PET/CT; it also shows the superiority of MSOT in differentiating melanoma metastases from other lymphadenopathies in mice in vivo.