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美国卫生研究院文献>Thorax
>Relation between exposure to fluoride and bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms.
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Relation between exposure to fluoride and bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms.
BACKGROUND--The relation between plasma fluoride levels and bronchial responsiveness was investigated in a longitudinal study in aluminium potroom workers who reported work-related asthmatic symptoms. METHODS--From a cross-sectional respiratory survey, 26 men who reported work-related asthmatic symptoms on a validated questionnaire were selected for repeated measurements of bronchial responsiveness to methacholine. Regular analyses of plasma fluoride levels were performed. Exposure to fluoride and total particulates was assessed from routine surveillance of the workplace. Bronchial responsiveness was expressed as the dose-response slope of the line through the origin and last data point. RESULTS--A positive association was found between bronchial responsiveness and plasma fluoride levels, such that an increase in the plasma fluoride level of 10 ng/ml was associated with an increase in the dose-response slope by a factor of 1.11 (95% confidence interval 1.05 to 1.17). Plasma fluoride levels were associated with the total atmospheric fluoride concentration in mg/m3 (beta = 28.1), but not with total particulates in the environment. CONCLUSIONS--Bronchial responsiveness in aluminium potroom workers reporting work-related asthmatic symptoms appears to be related to plasma levels of fluoride. The underlying mechanism is, however, unknown.
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机译:背景-在一项纵向铝质车间工人的纵向研究中,研究了血浆氟化物水平与支气管反应性之间的关系,这些工人报告了与工作有关的哮喘症状。方法-从一项横断面呼吸调查中,选择26名在经过验证的问卷上报告了与工作有关的哮喘症状的男性来重复测量支气管对乙酰甲胆碱的反应性。定期分析血浆氟化物水平。通过对工作场所的常规监测评估了氟和总颗粒的暴露。支气管反应性表示为通过原点和最后一个数据点的线的剂量反应斜率。结果-支气管反应性与血浆氟化物水平之间呈正相关,因此血浆氟化物水平增加10 ng / ml与剂量反应斜率增加1.11倍有关(95%置信度区间1.05至1.17)。血浆氟化物水平与总的大气氟化物浓度(mg / m3)有关(β= 28.1),但与环境中的总颗粒物无关。结论-报告与工作有关的哮喘症状的铝制车间工人的支气管反应性似乎与血浆氟化物水平有关。但是,其底层机制尚不清楚。
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