• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Oncology Letters >Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy
【2h】

Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy

机译：化疗后肝癌患者PTEN表达与肝功能及炎症变化的关系

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study investigated the effects of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression on liver function classification, serum tumor markers and liver function of patients with liver cancer. A total of 63 patients with primary liver cancer treated in Xiangya Hospital (Changsha, China) were retrospectively analyzed. The difference in the PTEN expression levels in normal liver cells and liver cancer cells was compared via immunohistochemistry. According to the expression level of PTEN in the patient's pathological report, patients were divided into PTEN-positive and PTEN-negative groups. The expression level of each tumor marker in serum of patients was observed, and the association of PTEN expression level with the serum tumor markers was analyzed. Moreover, the changes in liver function and inflammatory factors before and after chemotherapy were compared. Finally, the relationship between the PTEN expression level and Child-Pugh grading of the liver function was detected. Compared with that in normal liver cells, the positive expression rate of PTEN protein in liver cancer cells was significantly decreased (P<0.05). No significant difference was found in the expression levels of serum tumor markers, except α-fetoprotein (AFP) in liver cancer patients between PTEN-positive and PTEN-negative group, indicating that PTEN expression has no significant effects on serum tumor markers. The levels of albumin (ALB), alkaline phosphatase (ALP) and prothrombin activity (PTA) were decreased significantly after chemotherapy compared with those before chemotherapy (P<0.05). Besides, the levels of inflammatory factors were remarkably reduced after chemotherapy. PTEN expression was negatively associated with liver function grading, and the higher the PTEN expression, the lower the liver function grading was. The low expression of PTEN has a certain association with the occurrence and grading of liver cancer. PTEN gene has guiding significance in predicting the occurrence, development and prognosis of liver cancer.
机译：这项研究调查了磷酸酶和张力蛋白同源物缺失对十号染色体（PTEN）表达的影响，对肝癌患者的肝功能分类，血清肿瘤标志物和肝功能有影响。回顾性分析在长沙市湘雅医院治疗的63例原发性肝癌患者。通过免疫组织化学比较了正常肝细胞和肝癌细胞中PTEN表达水平的差异。根据患者病理报告中PTEN的表达水平，将患者分为PTEN阳性和PTEN阴性。观察患者血清中每种肿瘤标志物的表达水平，并分析PTEN表达水平与血清​​肿瘤标志物的关系。此外，比较了化疗前后肝功能和炎症因子的变化。最后，检测了PTEN表达水平与肝功能Child-Pugh分级之间的关系。与正常肝细胞相比，肝癌细胞中PTEN蛋白的阳性表达率明显降低（P <0.05）。在肝癌患者中，PTEN阳性和PTEN阴性组之间的血清肿瘤标志物表达水平没有显着差异，除了α-甲胎蛋白（AFP）外，这表明PTEN表达对血清肿瘤标志物没有显着影响。与化疗前相比，化疗后白蛋白（ALB），碱性磷酸酶（ALP）和凝血酶原活性（PTA）水平明显降低（P <0.05）。此外，化疗后炎症因子水平明显降低。 PTEN表达与肝功能分级呈负相关，PTEN表达越高，肝功能分级越低。 PTEN的低表达与肝癌的发生和分级有一定的联系。 PTEN基因在预测肝癌的发生，发展和预后中具有指导意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号