Robust Optimization in IMPT Using Quadratic Objective Functions to account for the minimum MU constraint

摘要

PurposeCurrently, in clinical practice of intensity-modulated proton therapy (IMPT), the influence of the minimum monitor unit (MU) constraint is taken into account through post-processing after the optimization is completed. This may degrade the plan quality and plan robustness. This study aims to mitigate the impact of the minimum MU constraint directly during the plan robust optimization.