Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers

机译：细胞周期阻滞生物标志物临床使用的临界值的推导和验证

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BackgroundAcute kidney injury (AKI) remains a deadly condition. Tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein (IGFBP)7 are two recently discovered urinary biomarkers for AKI. We now report on the development, and diagnostic accuracy of two clinical cutoffs for a test using these markers.

机译：背景急性肾损伤（AKI）仍然是致命的疾病。金属蛋白酶组织抑制剂（TIMP）-2和胰岛素样生长因子结合蛋白（IGFBP）7是最近发现的两种AKI尿液生物标志物。现在，我们报告使用这些标记物进行测试的两个临床临界值的发展情况和诊断准确性。

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期刊名称 Nephrology Dialysis Transplantation
作者
Eric A.J. Hoste; Peter A. McCullough; Kianoush Kashani; Lakhmir S. Chawla; Michael Joannidis; Andrew D. Shaw; Thorsten Feldkamp; Denise L. Uettwiller-Geiger; Paul McCarthy; Jing Shi; Michael G. Walker; John A. Kellum;
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年(卷),期 -1(29),11
年度 -1
页码 2054–2061
总页数 8
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;移植;
关键词
acute kidney injury acute renal failure biomarkers insulin-like growth factor binding protein (IGFBP)7 and tissue inhibitor of metalloproteinases (TIMP)-2 sensitivity and specificity (MeSH);

机译：急性肾损伤;急性肾衰竭;生物标志物;胰岛素样生长因子结合蛋白（IGFBP）7和金属蛋白酶组织抑制剂（TIMP）-2;敏感性和特异性（MeSH）;

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1. Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. [J] . Eric A J Hoste, Peter A McCullough, Kianoush Kashani, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2014,第11期

机译：细胞周期阻滞生物标志物临床使用的临界值的推导和验证。
2. Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. [J] . Eric A J Hoste, Peter A McCullough, Kianoush Kashani, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2014,第11期

机译：细胞周期逮捕生物标志物临床应用截止的衍生和验证。
3. Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication [J] . Azra Bihorac, Lakhmir S. Chawla, Andrew D. Shaw, American journal of respiratory and critical care medicine . 2014,第8期

机译：使用临床裁决验证急性肾损伤的细胞周期逮捕生物标志物。
4. Sensitivity of Derived Clinical Biomarkers to rs-fMRI Preprocessing Software Versions [C] . Kevin P. Nguyen, Cherise Chin Fatt, Cooper Mellema, IEEE International Symposium on Biomedical Imaging . 2019

机译：衍生的临床生物标记物对rs-fMRI预处理软件版本的敏感性
5. Identification and Clinical Validation of Novel Prostate Cancer Biomarkers Filamin A (FLNA), Filamin B (FLNB), and Keratin 19 (KRT19) Using Patient-Derived Omics and Bayesian Artificial Intelligence [D] . Narain, Niven Rajin. 2018

机译：使用患者衍生的OMIC和贝叶斯人工智能，新型前列腺癌生物标志物菲莫林A（FLNA），丝素B（FLNB）和角蛋白19（KRT19）的鉴定及临床验证
6. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury [O] . Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, 2013

机译：在人类急性肾损伤中细胞周期阻滞生物标志物的发现和验证
7. Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers [O] . Eric A.J. Hoste, Peter A. McCullough, Kianoush Kashani, 2014

机译：细胞周期逮捕生物标志物临床应用截止的衍生和验证

Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers

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