L-DEPRENYL REVERSES AGE-ASSOCIATED DECLINE IN SPLENIC NOREPINEPHRINE IL-2 AND IFN-γ PRODUCTION IN OLD FEMALE F344 RATS

摘要

Aging in female rats is associated with cessation of reproductive cycles, development of mammary cancer, and increased incidence of autoimmune diseases. Previously, we demonstrated an age-related decline in sympathetic noradrenergic (NA) innervation in spleen and lymph nodes of female F344 rats accompanied by significantly reduced natural killer cell activity, interleukin-2 and interferon-γ production, and T and B cell proliferation, suggesting possible links between sympathetic activity and immunosenescence.ObjectivesThe aim is to investigate the effects of L-(−)-deprenyl, a monoamine oxidase-B inhibitor, on sympathetic nervous system (SNS) and cell-mediated immune responses in old female rats.