High Glucose Upregulates Upstream Stimulatory Factor 2 in Human Renal Proximal Tubular Cells through Angiotensin II-Dependent Activation of CREB

摘要

Background/AimsWe have previously demonstrated that a transcription factor, upstream stimulatory factor 2 (USF2), regulates glucose-induced thrombospondin 1 expression and transforming growth factor-β activity in mesangial cells, and plays an important role in diabetic glomerulopathy. In this study, we determined whether USF2 expression in renal proximal tubular cells is regulated by glucose and contributes to diabetic tubulointerstitial fibrosis.