Radiation Exposure the ATM Gene and Contralateral Breast Cancer in the Womens Environmental Cancer and Radiation Epidemiology Study

摘要

BackgroundIonizing radiation is a known mutagen and an established breast carcinogen. The ATM gene is a key regulator of cellular responses to the DNA damage induced by ionizing radiation. We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women.