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Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children with Average-Risk Medulloblastoma

机译：氨磷汀可预防中度髓样母细胞瘤患儿顺铂诱发的耳毒性

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摘要

PurposeTo determine the role of amifostine as a protectant against cisplatin-induced ototoxicity in patients with average risk (AR) medulloblastoma treated with craniospinal radiotherapy and 4 cycles of cisplatin-based dose-intense chemotherapy and stem cell rescue.

机译：目的确定氨磷汀在经颅脊柱放疗和基于顺铂的强剂量化疗和干细胞抢救的4个周期的平均风险（AR）髓母细胞瘤患者中作为顺铂诱导的耳毒性保护剂的作用。

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期刊名称 Journal of Clinical Oncology
作者
Maryam Fouladi; Murali Chintagumpala; David Ashley; Stewart Kellie; Sridharan Gururangan; Tim Hassall; Lindsey Gronewold; Clinton F Stewart; Dana Wallace; Alberto Broniscer; Gregory A. Hale; Kimberly A. Kasow; Thomas E. Merchant; Brannon Morris; Mathew Krasin; Larry E. Kun; James M. Boyett; Amar Gajjar;
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作者单位

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年(卷),期 -1(26),22
年度 -1
页码 3749–3755
总页数 15
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
amifostine ototoxicity cisplatin;

机译：氨磷汀;耳毒性;顺铂;

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专利

1. Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma. [J] . Fouladi M, Chintagumpala M, Ashley D, Journal of Clinical Oncology . 2008,第22期

机译：氨磷汀可预防中度风险的髓母细胞瘤患儿顺铂引起的耳毒性。
2. Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma [J] . James G. Gurney, Johnnie K. Bass, Arzu Onar-Thomas, Neuro-Oncology . 2014,第6期

机译：评价氨磷汀对中度或高危髓母细胞瘤治疗儿童的顺铂引起的严重听力损失的保护作用
3. Cumulative Cisplatin Dose Is Not Associated With Event-Free or Overall Survival in Children With Newly Diagnosed Average-Risk Medulloblastoma Treated With Cisplatin Based Adjuvant Chemotherapy: Report From the Children's Oncology Group [J] . Rao Amulya A. Nageswara, Wallace Dana J., Billups Catherine, Pediatric blood & cancer . 2014,第1期

机译：顺铂辅助化疗治疗新诊断的平均风险髓母细胞瘤患儿的顺铂累积剂量与无事件或总体生存无关：儿童肿瘤学组的报告
4. Application of probabilistic fiber-tracking method of MR Imaging to measure impact of cranial irradiation on structural brain connectivity in children treated for medulloblastoma [C] . Elizabeth C. Duncan, Wilburn E. Reddick, John O. Glass, Conference on biomedical applications in molecular, structural, and functional imaging . 2016

机译：MR成像的概率纤维跟踪方法在测量颅脑照射对成髓细胞瘤患儿脑结构连通性的影响中的应用
5. Cisplatin-induced ototoxicity in the chinchilla animal model A micro-otoscope for drug delivery to the round window membrane [D] . Abbasi Mood, Zhoobin 2012

机译：Cisplatin诱导的栗鼠动物模型中的耳毒性是一种微耳镜给圆形窗膜的药物输送
6. Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma [O] . James G. Gurney, Johnnie K. Bass, Arzu Onar-Thomas, 2014

机译：评价氨磷汀对中度或高危髓母细胞瘤治疗儿童的顺铂引起的严重听力损失的保护作用
7. Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma [O] . Maryam Fouladi, Murali Chintagumpala, David Ashley, 2008

机译：Amifostine在患有平均风险Medulloblastoma的儿童中防止顺铂诱导的耳毒性

Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children with Average-Risk Medulloblastoma

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