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Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells

机译：乳腺癌中雌激素受体测量的标准化表明假阴性结果是阈强度而不是阳性细胞百分比的函数

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PurposeRecent misclassification (false negative) incidents have raised awareness concerning limitations of immunohistochemistry (IHC) in assessment of estrogen receptor (ER) in breast cancer. Here we define a new method for standardization of ER measurement and then examine both change in percentage and threshold of intensity (immunoreactivity) to assess sources for test discordance.

机译：目的最近的错误分类（假阴性）事件提高了人们对免疫组织化学（IHC）在评估乳腺癌中雌激素受体（ER）方面的局限性的认识。在这里，我们定义了一种用于标准化ER测量的新方法，然后检查百分比变化和强度阈值（免疫反应性）以评估测试不一致的来源。

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期刊名称 Journal of Clinical Oncology
作者
Allison W. Welsh; Christopher B. Moeder; Sudha Kumar; Peter Gershkovich; Elaine T. Alarid; Malini Harigopal; Bruce G. Haffty; David L. Rimm;
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年(卷),期 -1(29),22
年度 -1
页码 2978–2984
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells [J] . WelshA.W., MoederC.B., KumarS., Journal of Clinical Oncology . 2011,第22期

机译：乳腺癌中雌激素受体测量的标准化表明，假阴性结果是阈强度的函数，而不是阳性细胞的百分比
2. NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells. [J] . Gionet N, Jansson D, Mader S Journal of cellular biochemistry. . 2009,第3期

机译：NF-κB和雌激素受体α相互作用：雌激素受体阴性和阳性激素非依赖性乳腺癌细胞中的差异功能。
3. Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. [J] . Guo P, Dong XY, Zhao K International Journal of Cancer =: Journal International du Cancer . 2010,第1期

机译：雌激素诱导的KLF5与雌激素受体（ER）之间的相互作用抑制了ER阳性乳腺癌细胞中ER的功能。
4. Estrogen Receptor-Positive Breast Cancer: Traditional Prognostics, Molecular Pathology: A New Breast Cancer Taxonomy and 21st Century Personalized Prognostic and Predictive Assays [C] . Frederick L. Baehner International Symposium on Cancer Metastasis and the Lymphovascular system: Basis for Rational Therapy . 2009

机译：雌激素受体阳性乳腺癌：传统预测，分子病理：新的乳腺癌分类和21世纪个性化预测和预测测定
5. Gene regulation by estrogen and tamoxifen in estrogen-receptor positive and estrogen-receptor negative human breast cancer cells: Characterization and quantification by real-time PCR. [D] . Yuan, Xia. 2004

机译：雌激素受体阳性和雌激素受体阴性人类乳腺癌细胞中雌激素和他莫昔芬的基因调控：实时PCR的表征和定量。
6. Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells [O] . Peng Guo, Xue-Yuan Dong, Ke-Wen Zhao, -1

机译：KLF5和雌激素受体（ER）之间的雌激素诱导的相互作用抑制了ER在ER阳性乳腺癌细胞中的功能
7. β-Catenin Is a Positive Regulator of Estrogen Receptor-α Function in Breast Cancer Cells [O] . Doris Mayer, Sina Grebhardt, Fee Schmitt, 2011

机译：β-连环蛋白是乳腺癌细胞中雌激素受体-α功能的正调节因子

Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells

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