The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm2; P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level.
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机译：发育中的胎儿能够应付子宫内发生的氧气供应的生理减少。但是，尚不清楚在高海拔妊娠时是否会增加胎儿的微血管形成。将秘鲁普诺（3,840 m）的53名健康足月新生儿与海平面对照组进行了比较。确定了导管前后的动脉血氧饱和度（SpO2）。使用近红外光谱（NIRS）测量大脑和小腿肌肉区域组织的氧合。使用入射暗场成像无创测量皮肤微循环。秘鲁婴儿的产前和产后血氧饱和度分别为88.1％和88.4％，分别比海平面新生儿低10.4％和9.7％（P <0.001）。秘鲁新生儿的脑和区域血氧饱和度显着降低（脑：71.0对74.9％；区域：68.5对76.0％，P <0.001）。经皮测量的秘鲁新生儿的总血管密度比在海平面出生的新生儿高14％（29.7对26.0 mm / mm 2 ； P≤0.001）。这项研究表明，高海拔母亲出生的新生儿的微血管密度高于海平面出生的新生儿。
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