FOCUS on translational bioinformatics: The role of complementary bipartite visual analytical representations in the analysis of SNPs: a case study in ancestral informative markers

摘要

ObjectiveSeveral studies have shown how sets of single-nucleotide polymorphisms (SNPs) can help to classify subjects on the basis of their continental origins, with applications to case–control studies and population genetics. However, most of these studies use dimensionality-reduction methods, such as principal component analysis, or clustering methods that result in unipartite (either subjects or SNPs) representations of the data. Such analyses conceal important bipartite relationships, such as how subject and SNP clusters relate to each other, and the genotypes that determine their cluster memberships.