As an infectious fungus that affects the respiratory tract, Cryptococcus neoformans (C. neoformans) commonly causes asymptomatic pulmonary infection. C. neoformans may target the brain instead of the lungs and cross the blood-brain barrier (BBB) in the early phase of infection; however, this is dependent on successful evasion of the host innate immune system. During the initial stage of fungal infection, a complex network of innate immune factors are activated. C. neoformans utilizes a number of strategies to overcome the anti-fungal mechanisms of the host innate immune system and cross the BBB. In the present review, the defensive mechanisms of C. neoformans against the innate immune system and its ability to cross the BBB were discussed, with an emphasis on recent insights into the activities of anti-phagocytotic and anti-oxidative factors in C. neoformans.
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机译:作为影响呼吸道的传染性真菌,新隐球菌(C. neoformans)通常引起无症状的肺部感染。 C. neoformans可能在感染的早期阶段而不是肺部针对大脑,并穿过血脑屏障(BBB);然而,这取决于成功逃避宿主先天免疫系统。在真菌感染的初期,先天免疫因子的复杂网络被激活。新型梭菌利用多种策略克服宿主先天免疫系统的抗真菌机制并穿越血脑屏障。在本综述中,讨论了新孢梭菌对先天免疫系统的防御机制及其穿越血脑屏障的能力,重点是对新孢梭菌抗吞噬和抗氧化因子活性的最新见解。
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