Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells

摘要

OBJECTIVEThe physiologic significance of the nitric oxide (NO)/cGMP signaling pathway in islets is unclear. We hypothesized that cGMP-dependent protein kinase type I (cGKI) is directly involved in the secretion of islet hormones and glucose homeostasis.