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The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation

机译:神经调节蛋白/ ErbB2 / ErbB4信号在心脏中的作用特别是对心肌细胞增殖的影响

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摘要

The signaling complex consisting of the growth factor neuregulin-1 (NRG1) and its tyrosine kinase receptors ErbB2 and ErbB4 has a critical role in cardiac development and homeostasis of the structure and function of the adult heart. Recent research results suggest that targeting this signaling complex may provide a viable strategy for treating heart failure. Clinical trials are currently evaluating the effectiveness and safety of intravenous administration of recombinant NRG1 formulations in heart failure patients. Endogenous as well as administered NRG1 has multiple possible activities in the adult heart, but how these are related is unknown. It has recently been demonstrated that NRG1 administration can stimulate proliferation of cardiomyocytes, which may contribute to repair failing hearts. This review summarizes the current knowledge of how NRG1 and its receptors control cardiac physiology and biology, with special emphasis on its role in cardiomyocyte proliferation during myocardial growth and regeneration.
机译:由生长因子神经调节蛋白1(NRG1)及其酪氨酸激酶受体ErbB2和ErbB4组成的信号传导复合物,在成年心脏的心脏发育和体内稳态中起着至关重要的作用。最近的研究结果表明,靶向这种信号复合物可能提供治疗心力衰竭的可行策略。目前,临床试验正在评估在心力衰竭患者中静脉内注射重组NRG1制剂的有效性和安全性。内源性和给药NRG1在成年心脏中具有多种可能的活动,但是这些之间的相关性尚不清楚。最近已经证明,施用NRG1可以刺激心肌细胞的增殖,这可能有助于修复心脏衰竭。这篇综述总结了有关NRG1及其受体如何控制心脏生理和生物学的最新知识,特别强调了它在心肌生长和再生过程中在心肌细胞增殖中的作用。

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