Neurological effects of proprotein convertase subtilisin/kexin type 9 inhibitors: direct comparisons

机译：前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型抑制剂的神经学作用：直接比较

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AimsProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors considerably alter the lipid profile. We sought to examine the rates of ischaemic stroke and neurocognitive deficits in patients treated with and without PCSK9 inhibitors.

机译：AimsProprotein转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）抑制剂可显着改变脂质分布。我们试图检查接受或不接受PCSK9抑制剂治疗的患者的缺血性中风和神经认知功能障碍的发生率。

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期刊名称 European Heart Journal. Quality of Care Clinical Outcomes
作者
Navkaranbir S Bajaj; Nirav Patel; Rajat Kalra; Amier Ahmad; Anand Venkatraman; Garima Arora; Pankaj Arora;
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作者单位

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年(卷),期 -1(4),2
年度 -1
页码 132–141
总页数 10
原文格式 PDF
正文语种
中图分类护理学;
关键词
PCSK9 Cognition Stroke Meta-analysis;

机译：PCSK9;认知;中风;荟萃分析;
入库时间 2022-08-21 10:51:58

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专利

1. AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: An analysis from the LDL-C assessment with proprotein convertase subtilisin kexin type 9 monoclonal antibody inhibition combined with statin therapy (LAPLACE)-thrombolysis in myocardial infarction (TIMI) 57 Trial [J] . DesaiN.R., KohliP., GiuglianoR.P., Circulation: An Official Journal of the American Heart Association . 2013,第9期

机译：AMG145，一种针对9型前蛋白转化酶枯草杆菌素kexin的单克隆抗体，可显着减少接受他汀类药物治疗的高胆固醇血症患者的脂蛋白（a）：对LDL-C评估，对9种前蛋白转化酶枯草杆菌素kexin单克隆抗体联合他汀类药物疗法的抑制作用（LAPLACE ）溶栓在心肌梗死（TIMI）57中的试验
2. Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor-independent pathways [J] . CameronJ., BogsrudM.P., TvetenK., Translational research: the journal of laboratory and clinical medicine . 2012,第2期

机译：家族性高胆固醇血症患者的血清原蛋白转化酶枯草杆菌蛋白酶/ kexin 9型水平表明通过低密度脂蛋白受体非依赖性途径从血浆中清除了原蛋白转化酶枯草杆菌蛋白酶/ kexin 9型
3. Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study. [J] . Noguchi T, Kobayashi J, Yagi K, Atherosclerosis . 2011,第1期

机译：苯扎贝特和非诺贝特对糖耐量减低或2型糖尿病的血脂异常患者的循环蛋白9枯草杆菌蛋白酶/ kexin和脂肪细胞因子水平的影响比较：一项交叉研究的结果。
4. Towards Investigating the Role of Proprotein Convertase Subtilisin/Kexin Family (PCSK/7/9) in Cancer by Using Bioinformatics Motif Detection Technique [C] . Umar Draz, Sana Yasin, Shafiq Hussain, International Bhurban Conference on Applied Sciences and Technologies . 2021

机译：通过使用生物信息学主题检测技术来研究Proprotein转化酶枯草杆菌素/ kexin家族（PCSK / 7/9）的作用
5. Evaluation of the Interaction Between Proprotein Convertase Subtilisin/Kexin Type 9 and Sterol Carrier Protein-2 [D] . Ahranjani, Reza. 2017

机译：评价前蛋白转化酶枯草杆菌蛋白酶/ Kexin 9型与甾醇载体蛋白2的相互作用。
6. Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9 [O] . Hyun-Duk Jang, Sang Eun Lee, Jimin Yang, -1

机译：环化酶相关蛋白1是原蛋白转化酶枯草杆菌蛋白酶/ kexin 9型的结合伴侣是原蛋白转化酶枯草杆菌蛋白酶/ kexin 9型对低密度脂蛋白受体的降解所必需的
7. Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: Results from a crossover study [O] . Noguchi, Tohru, Kobayashi, Junji, Yagi, Kunimasa, 2011

机译：苯扎贝特和非诺贝特对糖耐量异常或2型糖尿病血脂异常患者循环前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型和脂肪细胞因子水平的影响比较：交叉研究的结果

Neurological effects of proprotein convertase subtilisin/kexin type 9 inhibitors: direct comparisons

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