Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter circulating TNF-alpha level and cardiovascular risk factor for ischemic stroke

摘要

BackgroundTumor necrosis factor-α (TNF-α) is one of the most typical pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. Increasing evidences have demonstrated the important role of TNF-α in the development of ischemic stroke, but studies examining the possible association with stroke or direct functional effects of polymorphisms in TNF-α have been contradictory.