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The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

机译：一氧化碳释放分子ALF-186通过可溶性鸟苷酸环化酶ß1介导缺血和再灌注损伤后大鼠视网膜神经节细胞的抗炎和神经保护作用

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BackgroundThe endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding inflammation in neuronal tissues has not been studied in detail. In this investigation, we aimed to analyze the effects of the CORM ALF-186 on neuro-inflammation and hypothesized that the soluble guanylate cyclase (sGC) is playing a decisive role.

机译：背景内源性产生的气体分子一氧化碳能够促进缺血再灌注损伤（IRI）后的器官保护。尚未详细研究一氧化碳释放分子（CORM）对神经元组织炎症的影响。在这项调查中，我们旨在分析CORM ALF-186对神经炎症的影响，并假设可溶性鸟苷酸环化酶（sGC）起着决定性作用。

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期刊名称 Journal of Neuroinflammation
作者
Felix Ulbrich; Claus Hagmann; Hartmut Buerkle; Carlos C. Romao; Nils Schallner; Ulrich Goebel; Julia Biermann;
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作者单位

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年(卷),期 2017(14),-1
年度 2017
页码 130
总页数 14
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Ischemia/reperfusion injury Carbon monoxide Neuro-inflammation Neuroprotection sGC-ß1 Heat shock proteins;

机译：缺血/再灌注损伤;一氧化碳;神经炎症;神经保护;sGC-ß1;热休克蛋白;

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专利

1. The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ?1 in rats’ retinal ganglion cells after ischemia and reperfusion injury [J] . Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Journal of neuroinflammation . 2017,第1期

机译：一氧化碳释放分子ALF-186通过可溶性鸟苷酸环化酶β1介导缺血和再灌注损伤后大鼠视网膜神经节细胞的抗炎和神经保护作用
2. Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury. [J] . Biermann J, Lagreze WA, Dimitriu C, Investigative ophthalmology & visual science . 2010,第7期

机译：用吸入一氧化碳进行预处理可保护大鼠视网膜神经节细胞免受缺血/再灌注损伤。
3. Preconditioning with Inhalative Carbon Monoxide Protects Rat Retinal Ganglion Cells from Ischemia/Reperfusion Injury [J] . Julia Biermann, Wolf A. Lagr?¨ze, Cornelia Dimitriu, Investigative ophthalmology & visual science . 2010,第7期

机译：吸入一氧化碳预处理可保护大鼠视网膜神经节细胞免受缺血/再灌注损伤
4. Protective Effects of CORM-3, a Water-Soluble Carbon-Monoxide-Releasing Molecule, in a Model of Vascular Inflammation [C] . A. Vannacci, P. Failli, L Giannini, Collegium Internationale Allergologicum . 2007

机译：CINM-3，一种水溶性一氧化碳释放分子的保护作用，血管炎症模型
5. In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model [D] . KITAMURA, Yuta 2019

机译：单一或联合使用局部神经保护和再生剂对大鼠视神经挤压模型中视网膜神经节细胞变性的体内作用
6. The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells [O] . Felix Ulbrich, Kai B. Kaufmann, Alexander Meske, -1

机译：视网膜神经节细胞缺血和再灌注损伤后CORM ALF-186通过激活p38 MAPK介导抗凋亡信号
7. The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury [O] . Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, 2017

机译：在缺血再灌注损伤后，通过大鼠视网膜神经节细胞中的可溶性胍基酸盐环化酶ß1介导抗炎和神经保护作用介导抗炎和神经保护作用

The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

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