The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

摘要

BackgroundTriggering receptor expressed on myeloid cells 2 (TREM2) and apolipoprotein E (APOE) are genetically linked to Alzheimer’s disease. Here, we investigated whether human ApoE mediates signal transduction through human and murine TREM2 and sought to identify a TREM2-binding domain in human ApoE.