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Metab2MeSH: annotating compounds with medical subject headings

机译:Metab2MeSH:以医学主题词注释化合物

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摘要

>Summary: Progress in high-throughput genomic technologies has led to the development of a variety of resources that link genes to functional information contained in the biomedical literature. However, tools attempting to link small molecules to normal and diseased physiology and published data relevant to biologists and clinical investigators, are still lacking. With metabolomics rapidly emerging as a new omics field, the task of annotating small molecule metabolites becomes highly relevant. Our tool Metab2MeSH uses a statistical approach to reliably and automatically annotate compounds with concepts defined in Medical Subject Headings, and the National Library of Medicine's controlled vocabulary for biomedical concepts. These annotations provide links from compounds to biomedical literature and complement existing resources such as PubChem and the Human Metabolome Database.>Availability: >Contact: >Supplementary information: are available at Bioinformatics online.
机译:>摘要:高通量基因组技术的进步已导致开发了多种资源,这些资源将基因与生物医学文献中包含的功能信息相关联。但是,仍然缺少尝试将小分子与正常和患病的生理联系起来的工具以及与生物学家和临床研究者有关的公开数据。随着代谢组学作为新兴的组学领域迅速兴起,注释小分子代谢物的任务变得越来越重要。我们的工具Metab2MeSH使用统计方法来可靠地自动注释具有医学主题词以及国家医学图书馆关于生物医学概念的受控词汇中定义的概念的化合物。这些注释提供了从化合物到生物医学文献的链接,并补充了诸如PubChem和人类代谢组数据库之类的现有资源。>可用性: >联系方式: >补充信息:可在生物信息学在线获得。

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