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The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice

机译：抗炎剂必达立抑制大鼠和高脂血症小鼠的新内膜形成

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摘要

AimsBindarit is an original compound with peculiar anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines, including the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8. In this study, we investigated the effect of bindarit on neointima formation using two animal models of arterial injury: rat carotid artery balloon angioplasty and wire-induced carotid injury in apolipoprotein E-deficient (apoE^−/−) mice.

机译：AimsBindarit是一种具有独特抗炎活性的原始化合物，因为它选择性抑制了炎症趋化因子亚家族，包括单核细胞趋化蛋白MCP-1 / CCL2，MCP-3 / CCL7和MCP-2 / CCL8。在这项研究中，我们使用两种动物动脉损伤模型研究了必达利对新内膜形成的影响：大鼠颈动脉球囊血管成形术和载脂蛋白E缺乏症（apoE ^{-/-）引起的线致颈动脉损伤老鼠。}

著录项

期刊名称 Cardiovascular Research
作者
Gianluca Grassia; Marcella Maddaluno; Angelo Guglielmotti; Giorgina Mangano; Giuseppe Biondi; Pasquale Maffia; Armando Ialenti;
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作者单位

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年(卷),期 -1(84),3
年度 -1
页码 485–493
总页数 9
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Bindarit Neointima hyperplasia Monocyte chemoattractant protein-1 Macrophages Vascular smooth muscle cells;

机译：Bindarit;新内膜增生;单核细胞趋化蛋白-1;巨噬细胞;血管平滑肌细胞;

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专利

1. The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice [J] . GrassiaG., MaddalunoM., GuglielmottiA., Cardiovascular Research . 2009,第3期

机译：抗炎剂必达利抑制大鼠和高脂血症小鼠的新内膜形成
2. The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice [J] . Gianluca Grassia1 Marcella Maddaluno1 Angelo Guglielmotti2 Giorgina Mangano2 Giuseppe Biondi2 Pasquale Maffia134 and Armando Ialenti1* Cardiovascular Research . 2009,第3期

机译：抗炎剂必达立抑制大鼠和高脂血症小鼠的新内膜形成
3. WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation [J] . JiSheng Hu, ShangJing Pi, MingRui Xiong, Molecules and cells . 2020,第8期

机译：WD重复域1缺乏通过调节平滑肌细胞迁移和增殖，抑制小鼠颈动脉的新炎。
4. Blockade of keratinocyte-derived chemokine inhibits endothelial recovery and enhances plaque formation after arterial injury in apolipo-protein E-deficient mice [C] . E. A. Liehn, A. Schober, C. Webe Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：表达角质形成细胞衍生的趋化因子抑制内皮恢复，并增强脂蛋白缺乏小鼠动脉损伤后的斑块形成
5. Design and Synthesis of α-Truxillic Acid-Based Fatty Acid Binding Protein Inhibitors as Anti-Nociceptive and Anti-Inflammatory Agents [D] . Clement, Timothy. 2018

机译：基于α-葡萄状酸的脂肪酸结合蛋白抑制剂的设计与合成抗伤害和抗炎剂
6. WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation [O] . JiSheng Hu, ShangJing Pi, MingRui Xiong, 2020

机译：WD重复域1缺乏通过调节平滑肌细胞迁移和增殖抑制小鼠颈动脉的新炎。
7. The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice [O] . Grassia, Gianluca, Maddaluno, Marcella, Guglielmotti, Angelo, 2009

机译：抗炎剂必达立抑制大鼠和高脂血症小鼠的新内膜形成
8. Immunomodulation by Agents Which Inhibit Suppressor Cells in Injured Mice [R] . Hansbrough, J. F. 1988

机译：抑制受损小鼠抑制细胞的药物的免疫调节作用

The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice

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