Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats

机译：肺动脉高压大鼠肺动脉TRPM8的下调

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BackgroundPulmonary hypertension (PH) is characterized by profound vascular remodeling and alterations in Ca²⁺ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Multiple transient receptor potential melastatin-related (TRPM) subtypes have been identified in vascular tissue. However, the changes in the expression and function of TRPM channels in pulmonary hypertension have not been characterized in detail.

机译：背景肺动脉高压（PH）的特征是深刻的血管重塑和肺动脉平滑肌细胞（PASMC）Ca ^{2 + 体内稳态的改变。在血管组织中已鉴定出多种瞬时受体电位的褪黑素相关（TRPM）亚型。但是，TRPM通道在肺动脉高压中的表达和功能的变化尚未详细描述。}

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期刊名称 Cellular Physiology and Biochemistry
作者
Xiao-Ru Liu; Qing Liu; Gai-Ying Chen; Ying Hu; James S.K. Sham; Mo-Jun Lin;
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作者单位

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年(卷),期 -1(31),6
年度 -1
页码 892–904
总页数 19
原文格式 PDF
正文语种
中图分类细胞生物学;人体生理学;
关键词
Transient receptor potential melastatin Pulmonary hypertension Calcium signaling Monocrotaline Chronic hypoxia Menthol;

机译：瞬时受体电位褪黑素;肺动脉高压;钙信号传导;莫诺他林;慢性缺氧;薄荷醇;
入库时间 2022-08-21 10:50:56

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专利

1. Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats [J] . Xiao-Ru Liu, Qing Liu, Gai-Ying Chen, Cellular Physiology and Biochemistry . 2013,第6期

机译：肺动脉高压大鼠肺动脉TRPM8的下调
2. Transient Receptor Potential Melastatin-8 Activation Induces Relaxation of Pulmonary Artery by Inhibition of Store-Operated Calcium Entry in Normoxic and Chronic Hypoxic Pulmonary Hypertensive Rats [J] . Mu Yun-Ping, Lin Da-Cen, Zheng Si-Yi, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2018,第3期

机译：瞬态受体潜在的旋蘑菇-8活化通过促进常氧和慢性缺氧肺高血压大鼠的储存钙入口抑制肺动脉诱导肺动脉释放
3. Preventive treatment with atorvastatin ameliorates endothelial dysfunction of small pulmonary arteries in monocrotaline-induced pulmonary hypertensive rats [J] . Lin Zhihong, Jiang Zhi, Huang Xiaodong, Clinical and experimental hypertension: CEH . 2017,第5a8期

机译：用阿托伐他汀预防治疗改善了六甲胺诱导的肺部高血压大鼠小肺动脉内皮功能障碍
4. Role of capacitative Ca~(2+) entry but not Na~+/Ca~(2+) exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries [C] . Silke. Becker, Gregory A. Knock, Vladimir Snetkov, Symposium on Signalling Pathways in Acute Oxygen Sensing . 2006

机译：电容性Ca〜（2+）进入但不是Na〜+ / Ca〜（2+）在大鼠肺内动脉缺氧血管收缩中的作用
5. Biaxial mechanical characterization and microstructure-driven modeling of elastic pulmonary artery walls of large mammals under hypertensive conditions. [D] . Kao, Philip Hsien-Lan. 2010

机译：高血压条件下大型哺乳动物弹性肺动脉壁的双轴力学表征和微观结构驱动模型。
6. Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats. [O] . J. C. Wanstall, S. R. ODonnell 1992

机译：对肺动脉高压大鼠肺动脉制剂对血管扩张药的反应。
7. Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats [O] . Xiao-Ru Liu, Qing Liu, Gai-Ying Chen, 2013

机译：TRpm8在肺动脉高压大鼠肺动脉中的下调作用
8. Venous Fragment Embolism to the Pulmonary Artery: A Rare Occurrence - Case Report and Literature Review of Venous Fragment Embolization to the Pulmonary Artery [R] . 2009

机译：静脉碎片栓塞肺动脉：罕见的发生 - 病例报告及静脉碎片栓塞肺动脉的文献综述

Down-Regulation of TRPM8 in Pulmonary Arteries of Pulmonary Hypertensive Rats

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