Krüppel –Like Factor 8 is a Stress-Responsive Transcription Factor that Regulates Expression of HuR

摘要

Background/Aims:HuR is an RNA-binding protein that regulates the post-transcriptional life of thousands of cellular mRNAs and promotes cell survival. HuR is expressed as two mRNA transcripts that are differentially regulated by cell stress. The goal of this study is to define factors that promote transcription of the longer alternate form.