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Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study

机译：晚期去分化脂肪肉瘤患者的Aplidin：法国肉瘤组单臂II期研究

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BackgroundPreclinical data have suggested a therapeutic role of JUN pathway activation in dedifferentiated liposarcoma (DDLPS) tumorigenesis. Aplidin^® is a drug inducing apoptosis through a strong, sustained activation of c-Jun NH2-terminal kinase.

机译：背景临床前数据表明JUN途径激活在去分化脂肪肉瘤（DDLPS）肿瘤发生中的治疗作用。 Aplidin ^{®是通过c-Jun NH2末端激酶的强而持续的活化诱导凋亡的药物。}

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期刊名称 Annals of Oncology
作者
M. Toulmonde; A. Le Cesne; S. Piperno-Neumann; N. Penel; C. Chevreau; F. Duffaud; C. Bellera; A. Italiano;
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作者单位

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年(卷),期 -1(26),7
年度 -1
页码 1465–1470
总页数 6
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
dedifferentiated liposarcoma JUN treatment Aplidin plitidepsin;

机译：去分化型脂肪肉瘤;JUN;治疗;Aplidin;脂蛋白;

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专利

1. Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study [J] . Toulmonde M., Le Cesne A., Piperno-Neumann S., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第7期

机译：晚期去分化脂肪肉瘤患者的Aplidin：法国肉瘤组单臂II期研究
2. Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study [J] . Toulmonde M., Le Cesne A., Piperno-Neumann S., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第7期

机译：晚期消化脂质脂肪瘤患者的APLIDIN：法国SARCOMA集团单臂第二期研究
3. GDC-0449 in patients with advanced chondrosarcomas: A French sarcoma group/US and French national cancer institute single-arm phase ii collaborative study [J] . ItalianoA., LeCesneA., BelleraC., Annals of oncology: official journal of the European Society for Medical Oncology . 2013,第11期

机译：GDC-0449在晚期软骨肉瘤患者中的应用：法国肉瘤组织/美国和法国国家癌症研究所单臂ii期合作研究
4. Feasibility studies to upgrade the Canada-France-Hawaii Telescope site for the next generation Canada-France-Hawaii Telescope [C] . Kei Szeto, David Loop, Alan McConnachie, Conference on ground-based and airborne telescopes IV . 2012

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5. Male Circumcision as a Bio-medical HIV Intervention Targeting Male Heterosexual Sexually Transmitted Disease (STD) Patients in China - An Acceptability Study and a Single-arm Test-of-concept Trial. [D] . Wang, Zixin. 2013

机译：男性包皮环切术作为针对中国男性异性恋性传播疾病（STD）患者的生物医学HIV干预-可接受性研究和单臂概念测试试验。
6. GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study [O] . A. Italiano, A. Le Cesne, C. Bellera, -1

机译：GDC-0449在晚期软骨肉瘤患者中的应用：法国肉瘤组织/美国和法国国家癌症研究所单臂二期合作研究
7. Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study [O] . M. Toulmonde, A. Le Cesne, S. Piperno-Neumann, 2015

机译：晚期消化脂质糖浆患者的APLIDIN：法国SARCOMA集团单臂期二期研究

Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study

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