14-linked 123-Triazole des-peptidic analogues of PNA (TzNA)

摘要

1,2,3-triazole analogues of PNA (TzNA) in which the amide link in backbone is replaced by triazole ring is synthesized on solid phase by ‘click’ chemistry and such triazolothymine PNA chimeric oligomers are shown to significantly stabilize the derived PNA2:DNA triplexes. With increasing number of triazole units in the backbone, single stranded PNA oligomers exhibit enhanced self-ordering.