The Effect of Immune Factors Tumor Necrosis Factor-α (TNF-α) and Agonistic Autoantibodies to the Angiotensin II Type I Receptor (AT1-AA) on Soluble fms-Like Tyrosine-1 (sFlt-1) and Soluble Endoglin (sEng) Production in Response to Hypertension During Pregnancy

摘要

BACKGROUNDPreeclampsia is considered a disease of immunological origin associated with abnormalities in inflammatory cytokines, tumor necrosis factor-α (TNF-α), and activated lymphocytes secreting AT1-AA. Recent studies have also demonstrated that an imbalance of angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1), and sEndoglin, exists in preeclampsia; however, the mechanisms that initiate their overproduction are unclear.