Synthesis and characterization of hybrid Anderson hexa­molybdoaluminates(III) functionalized with indometacin or cinnamic acid

摘要

The single-side Al-centred tris-functionalized hybrid organic–inorganic Anderson polyoxomolybdates (C16H36N)3[Al(OH)3Mo6O18(OCH2)3CNH(C10H8O)]·C9H7N·4CH3OH·5H2O (>AlMo6-NH-Cin; Cin is cinnamic acid, C10H₉O₂) and (C₁₆H₃₆N)₃[Al(OH)₃Mo₆O₁₈(OCH₂)₃CNH(C₁₉H₁₅ClNO₃)]·9H₂O (>AlMo₆-NH-Indo; Indo is indometacin, C₁₉H₁₆ClNO₄) have been prepared in a mild three-step synthesis and structurally characterized by single-crystal X-ray diffraction, ¹H NMR and IR spectroscopies and elemental analysis. Both >AlMo₆-NH-Cin and >AlMo₆-NH-Indo crystallize in the ortho­rhom­bic space group Pbca. The anti­bacterial activities of >AlMo₆-NH-Cin and >AlMo₆-NH-Indo against the Gram-negative human mucosal pathogen Moraxella catarrhalis were investigated by determination of the minimum inhibitory concentration, which is 32 µg ml⁻¹ for >AlMo₆-NH-Cin and 256 µg ml⁻¹ for >AlMo₆-NH-Indo.