Integrated analysis of genome-wide DNA methylation gene expression and protein expression profiles in molecular subtypes of WHO II-IV gliomas

摘要

BackgroundGlioma is the most common malignant primary brain tumor among adults, among which glioblastoma (GBM) exhibits the highest malignancy. Despite current standard chemoradiation, glioma is still invariably fatal. A further insight into the molecular background of glioma is required to improve patient outcomes.