(1α8β)-6β-Benzo­yloxy-6-dehydroxy­heteratisine from Aconitum zeravschanicum

摘要

The title compound, C29H37NO6, was isolated from Aconitum zeravschanicum and exhibits anti­arhythmic activity. It is a derivative of the diterpenoid alkaloid heteratisine and as such the core framework of the mol­ecule contains four six-membered, three seven-membered and one five-membered ring. The chair conformation of one of the meth­oxy-substituted six-membered rings is different from that observed in heteratisine hydro­bromide monohydrate. In the latter case, this ring adopts a boat conformation due to a stabilizing intra­molecular N—H⋯O hydrogen bond. In the crystal structure of the title compound, there is only one acidic H atom. This hydroxyl group forms an inter­molecular O—H⋯O hydrogen bond that links mol­ecules into infinite chains along the b axis.