Contribution of the TGFB1 Gene to Myocardial InfarctionSusceptibility

摘要

Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci –509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 cases) and in the control group of the same ethnic descent (198 controls). Significant association with MI was observed in carriage frequencies of the alleleTGFB1*–509T (p=0.046, OR =1.45, 95% CI: 1.02-2.06), genotypes TGFB1*869T/T (p=0.0024, OR =1.75, 95% CI: 1.22-2.51), andTGFB1*915G/G (p=0.048, OR=1.76, 95% CI: 1.05-2.97). Linkage disequilibrium analysis for these SNPs has shown that the associations revealed can be considered to be independent. A complex analysis of MI association with combinations of alleles/genotypes of said SNPs indicates their cumulative effect. An analysis of susceptibility to early-onset MI (≤ 50 years old) revealed a positive association of the alleleTGFB1*–509T (p=0.002, OR=2.24, 95% CI: 1.35-3.71) and genotypeTGFB1*869T/T(p=0.008, OR=1.93, 95% CI: 1.18-3.15), as well as theiradditivity. An analysis of susceptibility to recurrent MI revealed anassociation of the genotypeTGFB1*–509T/T(p=0.0078, OR=2.60, 95% CI: 1.28-5.28). The resultsobtained indicate the important role of theTGFB1gene insusceptibility to MI, including early-onset and recurrent MI, in Russians.