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Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents

机译：QO58-赖氨酸开启剂对神经元Kv7 / KCNQ / M通道的激活及其对啮齿类动物炎性疼痛的镇痛作用

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摘要

Aim:The aim of this study was to examine the activation of neuronal Kv7/KCNQ channels by a novel modified Kv7 opener QO58-lysine and to test the anti-nociceptive effects of QO58-lysine on inflammatory pain in rodent models.

机译：目的：本研究的目的是检查新型修饰的Kv7开启剂QO58-赖氨酸对神经元Kv7 / KCNQ通道的激活作用，并测试QO58-赖氨酸对啮齿类动物炎症痛的镇痛作用。

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期刊名称 Acta Pharmacologica Sinica
作者
Bo-chuan Teng; Yan Song; Fan Zhang; Tian-yang Ma; Jin-long Qi; Hai-lin Zhang; Gang Li; KeWei Wang;
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作者单位

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年(卷),期 2016(37),8
年度 2016
页码 1054–1062
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
QO58-lysine Kv7/KCNQ M-channel pharmacokinetics XE991 retigabine inflammatory pain;

机译：QO58-赖氨酸;Kv7 / KCNQ;M通道;药代动力学;XE991;瑞替加滨;炎性疼痛;

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专利

1. Activation of neuronal Kv7/KCNQ/M-channels by the opener Q058-lysine and its anti-nociceptive effects on inflammatory pain in rodents [J] . Bo-chuan TENG, Yan SONG, Fan ZHANG, 中国药理学报：英文版 . 2016,第008期

机译：Q058-赖氨酸开启剂对神经元Kv7 / KCNQ / M通道的激活及其对鼠炎症性疼痛的镇痛作用
2. Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices [J] . Hui PENG, Xi-ling BIAN, Fu-cui MA, 中国药理学报：英文版 . 2017,第009期

机译：电压门控神经元Kv7 / KCNQ / M通道的药理调制可改变大鼠前额叶皮质切片中锥体神经元的内在兴奋性和突触反应。
3. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. [J] . Redrobe JP, Nielsen AN Behavioural Brain Research: An International Journal . 2009,第2期

机译：神经元Kv7钾通道激活剂对躁狂症啮齿动物模型过度活跃的影响。
4. A real-time rodent neural interface for deciphering acute pain signals from neuronal ensemble spike activity [C] . Sile Hu, Qiaosheng Zhang, Jing Wang, Asilomar Conference on Signals, Systems and Computers . 2017

机译：实时啮齿动物神经接口，用于从神经元合奏尖峰活动中解密急性疼痛信号
5. Inflammatory and neuronal mechanisms of facet-mediated pain in the context of neck injury [D] . Dong, Ling 2011

机译：颈部损伤背景下小平面介导的疼痛的炎症和神经元机制
6. Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices [O] . Hui Peng, Xi-ling Bian, Fu-cui Ma, 2017

机译：电压门控神经元Kv7 / KCNQ / M通道的药理调制可改变大鼠前额叶皮质切片中锥体神经元的内在兴奋性和突触反应。
7. Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents [O] . Bo-chuan Teng, Yan Song, Fan Zhang, 2016

机译：通过开启器QO58-赖氨酸激活神经元KV7 / KCNQ / M频道及其对啮齿动物炎性疼痛的抗伤害影响

Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents

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