Isothiafludine a novel non-nucleoside compound inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

摘要

Aim:To investigate the action of isothiafludine (NZ-4), a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus (HBV) in vitro and in vivo.