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Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

机译：硫化氢通过上调BDNF-TrkB途径抑制高半胱氨酸诱导的大鼠海马内质网应激和神经元凋亡

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摘要

Aim:Homocysteine (Hcy) can elicit neuronal cell death, and hyperhomocysteinemia is a strong independent risk factor for Alzheimer's disease. The aim of this study was to examine the effects of hydrogen sulfide (H2S) on Hcy-induced endoplasmic reticulum (ER) stress and neuronal apoptosis in rat hippocampus.

机译：目的：同型半胱氨酸（Hcy）可以引起神经元细胞死亡，高同型半胱氨酸血症是阿尔茨海默氏病的重要独立危险因素。这项研究的目的是检查硫化氢（H2S）对Hcy诱导的大鼠海马内质网（ER）应激和神经元凋亡的影响。

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期刊名称 Acta Pharmacologica Sinica
作者
Hai-jun Wei; Jin-hua Xu; Man-hong Li; Ji-ping Tang; Wei Zou; Ping Zhang; Li Wang; Chun-yan Wang; Xiao-qing Tang;
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作者单位

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年(卷),期 2014(35),6
年度 2014
页码 707–715
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
hydrogen sulfide homocysteine neurotoxicity hippocampus apoptosis ER stress BDNF tyrosine protein kinase B Alzheimers disease;

机译：硫化氢;高半胱氨酸;神经毒性;海马;细胞凋亡;内质网应激;BDNF;酪氨酸蛋白激酶B;阿尔茨海默氏病;

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专利

1. Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway [J] . Hai-jun WEI, Jin-hua XU, Man-hong LI, 中国药理学报：英文版 . 2014,第006期

机译：硫化氢通过上调BDNF-TrkB途径抑制高半胱氨酸诱导的大鼠海马内质网应激和神经元凋亡
2. Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats [J] . LiM.-H., TangJ.-P., ZhangP., Behavioural Brain Research: An International Journal . 2014,第Null期

机译：海马内源性硫化氢生成和内质网应激障碍与同型半胱氨酸诱导的大鼠学习记忆障碍有关
3. Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells [J] . Sun-Oh Jeong, Yong Son, Ju Hwan Lee, Biochemical and Biophysical Research Communications . 2017,第1期

机译：一氧化氮和亚硝酸盐防止同型半胱氨酸诱导的内质网应激和随后通过神经元细胞的CGMP依赖性途径凋亡
4. Endoplasmic Reticulum Stress Signaling Pathways Is Involved in Trichosanthin-Induced Apoptosis in Human Cervical Cancer Cell Line Hela [C] . Huang Yiling, Huang Liming, You Chengcheng, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：内质网应激信号通路涉及天花粉蛋白诱导的人宫颈癌细胞株Hela的凋亡。
5. Palmitate-induced apoptosis in retinal pericytes: Roles of oxidative stress, NF-[kappa]B, ceramide, endoplasmic reticulum stress and AMP -activated protein kinase [D] . Cacicedo, Jose Maria 2009

机译：棕榈酸酯诱导的视网膜周细胞凋亡：氧化应激，NF-κB，神经酰胺，内质网应激和AMP激活的蛋白激酶的作用
6. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway [O] . Min Hu, Wei Zou, Chun-Yan Wang, 2016

机译：硫化氢可通过上调BDNF-TrkB途径防止海马慢性不可预测的轻度应激诱导的氧化应激
7. Hydrogen sulfide inhibits formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1. [O] . Xiang Li, Kai-Yan Zhang, Ping Zhang, 2014

机译：硫化氢通过上调sIRT-1抑制pC12细胞中甲醛诱导的内质网应激。

Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

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