Phase I study on the pharmacokinetics and tolerance of ZT-1 a prodrug of huperzine A for the treatment of Alzheimers disease

摘要

Aim:Huperzine A isolated from the Chinese herb Huperzia serrata (Thunb) Trev is a novel reversible and selective AChE inhibitor. The aim of this study was to evaluate the pharmacokinetics and tolerance of single and multiple doses of ZT-1, a novel analogue of huperzine A, in healthy Chinese subjects.