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Enhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in mice

机译：BPD-MA介导的光动力疗法联合阿霉素对小鼠乳腺癌的增强抗肿瘤作用

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摘要

Aim:Photodynamic therapy (PDT) is an emerging treatment used to eradicate premalignant and early-stage cancers and to reduce tumor size in end-stage cancers. In this study, we investigated the effects of a combination of benzoporphyrin derivative monoacid ring A (BPD-MA)-mediated PDT with adriamycin (ADM) on 4T1 breast carcinoma cells in vivo and the mechanisms underlying this effect.

机译：目的：光动力疗法（PDT）是一种新兴的治疗方法，用于根除恶变前和早期癌症并缩小晚期癌症的肿瘤大小。在这项研究中，我们研究了苯并卟啉衍生物单酸环A（BPD-MA）介导的PDT与阿霉素（ADM）的组合在体内对4T1乳腺癌细胞的作用及其潜在机制。

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期刊名称 Acta Pharmacologica Sinica
作者
Zhong-sheng Tong; Pei-tian Miao; Ting-ting Liu; Yong-sheng Jia; Xiao-dong Liu;
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作者单位

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年(卷),期 2012(33),10
年度 2012
页码 1319–1324
总页数 6
原文格式 PDF
正文语种
中图分类药学 ;
关键词
breast cancer photodynamic therapy benzoporphyrin derivative monoacid ring A (BPD-MA) adriamycin xenograft apoptosis Bax Bcl-2 angiogenesis;

机译：乳腺癌;光动力疗法;苯并卟啉衍生物单酸环A（BPD-MA）;阿霉素;异种移植;凋亡;Bax;Bcl-2;血管生成;

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专利

1. Enhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in mice [J] . Zhong-sheng TONG, Pei-tian MIAO, Ting-ting LIU, 中国药理学报：英文版 . 2012 ,第010期

机译：BPD-MA介导的光动力疗法联合阿霉素对小鼠乳腺癌的增强抗肿瘤作用
2. Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models [J] . Hou WL, Chen LJ, Yang GL, Phytotherapy research: PTR . 2008 ,第8期

机译：脂质体厚朴酚联合阿霉素对乳腺癌模型的协同抗肿瘤作用
3. Antitumor effect of combined Dkk-3 and 5-ALA mediated photodynamic therapy in breast cancer cell's colony [J] . Mohammadpour Henan, Fekrazad Reza Photodiagnosis and Photodynamic Therapy . 2016 ,第juna期

机译：Dkk-3和5-ALA联合光动力疗法对乳腺癌细胞集落的抗肿瘤作用
4. New cancer-treatment model of photodynamic therapy combined with a type I topoisomerase inhibitor CPT-11 against HeLa cell tumors in nude mice used by OPO parametric tunable laser [C] . Takato O. Yoshida, Hamamatsu Univ. School of Medicine, Hamamatsu, 5th International Photodynamic Association Biennial Meeting . 1995

机译：OPO参数可调激光使用光动力疗法联合I型拓扑异构酶抑制剂CPT-11对抗裸鼠HeLa细胞肿瘤的新癌症治疗模型
5. The Anti-tumor and Anti-angiogenic Effects of Photodynamic Therapy with Pheophorbide a on Breast Cancer in vitro and in vivo. [D] . Hoi, Wan Heng. 2011

机译：磷脂酰磷光动力疗法在体外和体内对乳腺癌的抗肿瘤和抗血管生成作用。
6. Enhanced Antitumor Effects of Epidermal Growth Factor Receptor Targetable Cetuximab-Conjugated Polymeric Micelles for Photodynamic Therapy [O] . Ming-Hsiang Chang, Chin-Ling Pai, Ying-Chen Chen, 2018

机译：表皮生长因子受体可靶向的西妥昔单抗缀合的聚合物胶束的光动力疗法的增强的抗肿瘤作用。
7. Chemotherapy is one of the therapies for cancer patients that cause some side effects, one of them is nausea and vomiting. Nausea and vomiting are still felt by patients even though they take antiemetics. Nausea dan vomiting can cause fluid and electrolyte imbalance. The aim of this study was to analysis the effect of combination acupressure wristband and antiemetic among chemotherapy induced nausea vomiting (CINV) on breast cancer patients. This research used quasi experimental research method, with a pre-post test with the control group. The sampling techniques was consecutive sampling with 25 respondents both in intervention group and control group. In the intervention group had received an acupressure wristband. CINV measured on the second day until fourth day after chemotherapy. Nausea and vomiting score were measured twice a day by a telemonitoring methode by Rhodes Index Nausea, Vomiting and Retching (INVR) questionaire. Data were analyzed by paired t-test, independent t-test, Wilcoxon test and Mann Whitney. The result of this study showed that acupressure wristband significantly reduce the chemotherapy induced nausea and vomit (p value = 0.000). The use of acupressure wristband combined with antiemetic therapy can significantly decrease chemotherapy induced nausea and vomiting in breast cancer patients. Acupressure wristband recommended for consideration nursing intervention in treating breast cancer patients who experience nausea and vomiting. [O] . Endah Fatma 2018

机译：化疗是癌症患者的疗法之一，导致一些副作用，其中一个是恶心和呕吐。患者仍然感受到恶心和呕吐，即使他们服用助性学。恶心丹呕吐会导致液体和电解质不平衡。本研究的目的是分析组合组合腕带和抑制在乳腺癌患者中的诱导恶心呕吐（CINV）的影响。本研究使用了准实验研究方法，用对照组进行了预先测试。采样技术是在干预组和对照组中进行25名受访者的连续抽样。在干预组中，收到了一名腕带。 Cinv在化疗后第四天测量。通过罗得岛指数恶心，呕吐和转换（INVR）问卷，每天测量恶心和呕吐分数。通过配对的T检验，独立的T检验，Wilcoxon测试和Mann Whitney分析数据。该研究的结果表明，Acuruce腕带显着降低化疗诱导的恶心和呕吐物（P值= 0.000）。使用Acu压抑腕带与止吐疗法相结合，可以显着降低乳腺癌患者诱导的恶心和呕吐。 Acu压痕腕带推荐用于治疗体验恶心和呕吐的乳腺癌患者的护理干预。
8. Combined Therapy for Non-Resectable Squamous Cell Carcinoma of the Oral Cavity. Local Selective Intra-Arterial Infusion with Adriamycin and Bleomycin Combined Concurrently with Radiotherapy. The Predictive Value of Flow Cytometry in Monitoring Cell Cycle Kinetic Effects of Therapy [R] . Noorman van der Dussen, M. F. 1986

机译：口腔不可切除鳞状细胞癌的联合治疗。局部选择性动脉内注射阿霉素和博来霉素联合放疗。流式细胞术在监测细胞周期动力学疗效中的预测价值

Enhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in mice

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