The Inhibitory Activity of the Extracts of Popular Medicinal Herbs on CYP1A2 2C9 2C19 and 3A4 and the Implications for Herb-Drug Interaction

机译：常用中草药提取物对CYP1A2、2C9、2C19和3A4的抑制活性及其对药-药相互作用的影响

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BackgroundStudies have suggested an increasing practice of concurrent herb-drug consumption. One of the major clinical risks of such concomitant herb-drug use is pharmacokinetic herb-drug interaction (HDI). This is brought about by the ability of phytochemicals to inhibit or induce the activity of metabolic enzymes. The aim of this study was to investigate the potential of the crude aqueous extracts of three popular medicinal herbs used in South Africa to inhibit major cytochrome P450 (CYP) enzymes.

机译：背景研究表明，人们越来越多地同时食用草药。这种同时使用草药-药物的主要临床风险之一是药代动力学草药-药物相互作用（HDI）。这是由植物化学物质抑制或诱导代谢酶活性的能力引起的。这项研究的目的是调查在南非使用的三种常用药草的粗制水提取物抑制主要细胞色素P450（CYP）酶的潜力。

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期刊名称 African Journal of Traditional Complementary and Alternative Medicines
作者
Pius S Fasinu; Patrick J Bouic; Bernd Rosenkranz;
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作者单位

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年(卷),期 2014(11),4
年度 2014
页码 54–61
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
Cytochrome P450 drug metabolism enzyme inhibition herb-drug interaction liver microsomes;

机译：细胞色素P450;药物代谢;酶抑制;中药相互作用;肝微粒体;

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1. An in vitro affinity-based method for studying herb-drug interactions for direct identification of cytochrome P450 1A2, 3A4, and 2C9 specific ligands from herbal extracts using ultrafiltration-high performance liquid chromatography [J] . Wang Zhiqiang, Hwang Seung Hwan, Zuo Guanglei, RSC Advances . 2018,第16期

机译：使用超滤 - 高效液相色谱法从草本提取物直接鉴定细胞色素P450 1A2,3A4和2C9特异性配体的研究中的一种体外亲和力的方法
2. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions [J] . Thomford Nicholas Ekow, Dzobo Kevin, Chopera Denis, Molecules . 2016,第7期

机译：药用植物提取物Newbouldia laevis和Cassia abrbreviata的体外可逆和时效性CYP450抑制特征：对药-药相互作用的影响
3. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata : Implications for Herb-Drug Interactions [J] . Nicholas Ekow Thomford, Kevin Dzobo, Denis Chopera, Molecules . 2016,第7期

机译：药用草本植物提取物Newbouldia laevis和Cassia abbreviata的体外可逆和时效CYP450抑制特征：对药-药相互作用的影响
4. Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation [C] . Zhijie Cui, Hong Kang, Kailin Tang, International symposium on bioinformatics research and applications . 2014

机译：感应药与药相互作用的研究中，针对抗孕烷X受体从药草中筛选成分：结合药理学和基于坞站的等级汇总
5. An integrative systems approach to predict herb-drug interactions quantitatively. [D] . Gufford, Brandon Tyler. 2015

机译：一种集成系统方法，可定量预测草药-药物相互作用。
6. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions [O] . Nicholas Ekow Thomford, Kevin Dzobo, Denis Chopera, 2016

机译：药用植物提取物Newbouldia laevis和Cassia abbreviata的体外可逆和时效CYP450抑制特征：对草药-药物相互作用的影响
7. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions [O] . Nicholas Ekow Thomford, Kevin Dzobo, Denis Chopera, 2016

机译：体外可逆和时间依赖性CYp450抑制药用草药植物提取物Newbouldia laevis和Cassia abbreviata：对药物相互作用的影响

The Inhibitory Activity of the Extracts of Popular Medicinal Herbs on CYP1A2 2C9 2C19 and 3A4 and the Implications for Herb-Drug Interaction

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