Study of vascular injuries using endothelial denudation model and the therapeutic application of shock wave: a review

摘要

As death toll from cardiovascular diseases has reached historic heights in the developed world, research efforts have been focused on both the understanding of disease progression and also the choice of appropriate treatment strategies. Moreover, to facilitate research, an appropriate animal model is needed to mimic the pathological changes and follow treatment results. This article reviewed the disease mechanisms underlying vascular injuries and also the animal model of endothelial denudation using balloon catheter. On the other hand, the biological effects of shock wave including angiogenesis and the suppression of inflammation were reviewed. Its therapeutic impact on the cardiovascular system and its potential clinical application as well as limitations were also discussed.