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Anonymous Record Linkage Between EPR and CDW-H: Toward Development of a Federated Genotype-Phenotype System

机译:EPR和CDW-H之间的匿名记录链接:联邦基因型-表型系统的发展。

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摘要

Environmental Polymorphisms Registry (EPR) is a large-scale phenotype-by-genotype registry developed by National Institute of Environmental Health Sciences to facilitate translational research. The link between personal identity and collected genomic data was preserved in EPR which creates opportunities for EPR to be linked to phenotype-rich databases, such as the Carolina Data Warehouse for Health (CDW-H) located at the University of North Carolina hospital system. CDW-H contains clinically-relevant data for patients who have been admitted to UNC healthcare system. To validate the feasibility of linking EPR with CDWH, the number of matching records between the two databases had to be established. To that end, combinations of subjects’ demographic identifiers from both databases were converted to anonymized hash codes, which were then matched to determine the number of overlapping records. Preliminary results showed that combination of last name, gender, data of birth and zip code would generate over 2,700 matches between the two databases.
机译:环境多态性注册表(EPR)是由美国国家环境卫生科学研究所开发的大型按表型逐基因型注册表,旨在促进翻译研究。 EPR保留了个人身份与收集的基因组数据之间的联系,这为EPR创造了与丰富表型数据库链接的机会,例如位于北卡罗来纳大学医院系统的卡罗来纳州健康数据仓库(CDW-H)。 CDW-H包含已被UNC医疗系统接纳的患者的临床相关数据。为了验证将EPR与CDWH链接的可行性,必须确定两个数据库之间匹配记录的数量。为此,将来自两个数据库的受试者的人口统计学标识符的组合转换为匿名的哈希码,然后对其进行匹配以确定重叠记录的数量。初步结果显示,姓,性别,出生数据和邮政编码的组合将在两个数据库之间产生超过2,700个匹配项。

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