Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis

机译：原发性胆源性胆管炎患者血清中抗核蛋白p62自身抗体的检测

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BackgroundPrimary biliary cholangitis (PBC) is an autoimmune liver disease characterized by specific autoantibodies. We evaluated the prevalence of autoantibodies against nucleoporin p62 (anti-p62) in PBC patients' sera to determine whether it can be a marker for PBC, in comparison with other immunological and biochemical parameters. We validated the performance of our in-house ELISA technique.

机译：背景原发性胆汁性胆管炎（PBC）是一种以自身抗体为特征的自身免疫性肝病。我们评估了PBC患者血清中针对核孔蛋白p62（anti-p62）的自身抗体的流行程度，以确定其是否可以作为PBC的标志物，并与其他免疫学和生化指标进行了比较。我们验证了我们内部ELISA技术的性能。

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期刊名称 Annals of Laboratory Medicine
作者
Alicja Bauer; Andrzej Habior;
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作者单位

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年(卷),期 2019(39),3
年度 2019
页码 291–298
总页数 8
原文格式 PDF
正文语种
中图分类情报学;
关键词
Nucleoporin p62 Primary biliary cholangitis ELISA Autoantibodies Liver Recombinant protein;

机译：核蛋白p62;原发性胆源性胆管炎;ELISA;自身抗体;肝脏;重组蛋白;

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专利

1. Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis [J] . Alicja Bauer, Andrzej Habior Annals of laboratory medicine. . 2019,第3期

机译：原发性胆源性胆管炎患者血清中核蛋白p62自身抗体的检测
2. Evaluation of the United Kingdom‐primary biliary cholangitis and global primary biliary cholangitis group prognostic models for primary biliary cholangitis patients treated with ursodeoxycholic acid in the U.S. population [J] . Mohammad Alomari, Fahrettin Covut, Laith Al Momani, JGH OPEN . 2020,第2期

机译：基前胆囊炎与丙酮酸胆酸治疗原发性胆管炎患者的英国原发性胆管炎和全球原发性胆囊炎群预后模型
3. Primary biliary cirrhosis sera recognize not only gp210 but also proteins of the p62 complex bearing N-acetylglucosamine residues from rat liver nuclear envelope Anti-p62 complex antibody in PBC [J] . K. Miyachi, M.Shibata, Y. Onozuka, Molecular biology reports . 1996,第3a4期

机译：原发性胆汁性肝硬化血清不仅识别gp210，而且识别P62复合物的蛋白质，该蛋白质带有来自大鼠肝核包膜的N-乙酰氨基葡糖残基PBC中的抗p62复合物抗体
4. Ursodeoxycholic Acid therapy Affects the Cytokine Network and Plays An Immunomodulatory Role in Patients With Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis [C] . M. G. Neuman, P. Angulo, I. M. Malkiewicz, Falk Symposium . 2003

机译：核糖核酸酸治疗影响细胞因子网络，并对初级硬化胆管炎和原发性胆汁肝硬化患者发挥免疫调节作用
5. Predicting outcomes post liver transplantation in patients with primary biliary cirrhosis and primary sclerosing cholangitis. [D] . Zapatochny Rufo, Rebecca Jo. 2003

机译：预测原发性胆汁性肝硬化和原发性硬化性胆管炎患者肝移植后的结局。
6. Analysis of Autoantibodies against Promyelocytic Leukemia Nuclear Body Components and Biochemical Parameters in Sera of Patients with Primary Biliary Cholangitis [O] . Alicja Bauer, Andrzej Habior, Paulina Wieszczy, 2021

机译：对原发性胆管炎患者血清血清细胞白血病核体成分的自身抗体分析及生物化学参数
7. Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis [O] . Alicja Bauer, Andrzej Habior 2019

机译：检测原发性胆囊炎患者血清核偶胆素P62的自身抗体

Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis

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