Examination using LC-MS/MS determination of grayanotoxin levels in blood urine and honey consumed by patients presenting to the emergency department with mad honey intoxication and relations with clinical data: a preliminary study

摘要

BACKGROUND AND OBJECTIVEIntoxications related to ”mad honey” are frequently encountered in the Black Sea region of Turkey. Intoxication is established on the basis of whether honey was consumed when history was taken at presentation. The search for a simple and reliable method for showing the grayanotoxins (GTXs) in mad honey in body fluids and in honey consumed by patients is still at the research stage. The purpose of this preliminary study was to investigate GTX levels in blood, urine, and honey consumed by patients with mad honey intoxication and to determine whether there is an association with clinical status.