AB074. Genetic variation in CYP2U1 CYP4A11 and CYP4F2 involved in the biosynthesis of hydroxyeicosatetraenoic acids and susceptibility to hypertension and atherosclerosis of various locations

摘要

Background20-hydroxyeicosatetraenoic acids (20-HETE), products of arachidonic acid metabolism, possess a wide spectrum of important functions in the cardiovascular system and thereby may contribute to the development of many cardiovascular diseases (CVD). CYP2U1, CYP4A11 and CYP4F2 are important enzymes involved in the biosynthesis of 20-HETE and their genetic polymorphisms became attractive markers for testing of the genetic susceptibility to CVD. The present study investigated association between single nucleotide polymorphisms (SNP) of genes coding CYP2U1 (rs1493131), CYP4A11 (rs3890011, rs9332978, rs9333029), CYP4F2 (rs3093098, rs1558139), enzymes involved in the 20-HETE metabolism, and risk of various CVDs.