CYP4F2基因多态性与原发性高血压易感性的相关性研究

摘要

目的 探讨浙江地区不同性别汉族人群中CYP4F2基因多态性与原发性高血压易感性的相关性.方法 以690例原发性高血压患者(观察组)和656例非高血压患者(对照组)为研究对象,运用TaqMan荧光定量法对CYP4F2(rs1558139、rs2108622)进行基因分型,应用非条件logistic回归和多因子降维法软件按性别分析CYP4F2基因多态性与高血压的相关性.结果 两组间无论男女,其年龄、BMI、总胆固醇、甘油三酯的差异均有统计学意义(均P＜0.01),而且两组间男性饮酒和体力活动分布的差异有统计学意义(P＜0.05).仅在女性对象中,观察组rs2108622的A等位基因的分布频率明显高于对照组,差异有统计学意义(P＜0.05).男性中rs1558139 CC基因型进入最终模型(P＜0.05);女性中rs2108622 AA+AG基因型进入最终模型,但差异无统计学意义(P ＞0.05).MDR分析未见CYP4F2基因多态与环境暴露之间存在交互作用.结论 CYP4F2 rs1558139 CC基因型可增加男性患高血压的风险.%To investigate the association between genetic polymorphisms of CYP4F2 and susceptibility of es-sential hypertension (EH).Two SNPs of CYP4F2 (rs1558139 and rs2108622) were genotyped by using TaqMan as-say in 690 EH patients and 656 healthy controls. Unconditional logistic regression and multifactor dimensionality reduction! MDR) methods were adopted to analyze the data by gender.ResultsThere were statistically significant differences in age, BMI, totalcholesterol and triglycerides between two groups in both genders (P<0.01), and the differences were also detected in activities and drinking in males (P<0.05). Comparing the frequencies of alleles and genotypes, there were no significant differences except frequency of allele A of rs2108622 in female group (P<0.05). The unconditional logistic regression showed that the CC genotype of rs1558139 was a risk factor for EH in males (P<0.05). In females, rs2108622 AA+AG genotypes were also selected into the final model, but the significant difference was not observed (P >0.05). There were no interaction between SNP of CYP4F2 and EH in MDR analysis.ConclusionThis study suggests that the CC genotype of rs1558139 might be associated with EH inmales.