Emergence of the Quinolone Resistance-Mediating Gene aac(6′)-Ib-cr in Extended-Spectrum-β-Lactamase-Producing Klebsiella Isolates Collected in Slovenia between 2000 and 2005

摘要

Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-β-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6′)-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.