FKS1 Mutations Responsible for Selective Resistance of Saccharomyces cerevisiae to the Novel 13-β-Glucan Synthase Inhibitor Arborcandin C

摘要

Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-β-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn⁴⁷⁰ with Lys or of Leu⁶⁴² with Ser confers selective resistance on Fks1p mutants.