Note: Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam a Novel Aminopenicillin–β-Lactamase Inhibitor Combination against Escherichia coli

摘要

We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a novel drug combination, and its pharmacodynamics against Escherichia coli in 12 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericidal and urine inhibitory activities in most volunteers were observed against E. coli strains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 strains) and high (≥16-mg/liter) (47 strains), respectively.