Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat

机译：乙酰左旋肉碱（ALCAR）的多种给药策略无法改变Fischer 344 / NHsd大鼠与年龄有关的听力损失

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

获取外文期刊封面目录资料

页面导航

摘要
著录项
引文网络
相似文献
相关主题

摘要

BackgroundThe Fischer 344/NHsd rat undergoes age-related, progressive, high-frequency hearing loss beginning at age 12 months. The loss has been linked to defects/death in the outer hair cells related to oxidative stress originating in the mitochondria. Acetyl L-carnitine (ALCAR) is known to enhance mitochondrial bioenergetics and membrane efficiency. Therefore, ALCAR was targeted as a possible pharmacologic intervention to prevent, or even restore, hearing loss from aging.

机译：背景Fischer 344 / NHsd大鼠从12个月大时开始经历与年龄相关的进行性高频听力损失。该损失与外部线粒细胞中与源自线粒体的氧化应激有关的缺陷/死亡有关。乙酰基L-肉碱（ALCAR）可以增强线粒体的生物能和膜效率。因此，ALCAR的目标是作为预防或什至恢复因衰老而引起的听力损失的可能的药物干预措施。

著录项

期刊名称 Journal of Negative Results in Biomedicine
作者
Eric C Bielefeld; Donald Coling; Guang-Di Chen; Donald Henderson;
展开▼
作者单位

展开▼
年(卷),期 2008(7),-1
年度 2008
页码 4
总页数 5
原文格式 PDF
正文语种
中图分类生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat [J] . Eric C Bielefeld, Donald Coling, Guang-Di Chen, Journal of negative results in biomedicine . 2008,第15期

机译：乙酰左旋肉碱（ALCAR）的多种给药策略无法改变Fischer 344 / NHsd大鼠的年龄相关性听力损失
2. Age-related hearing loss patterns in Fischer 344/NHsd rats with cisplatin-induced hearing loss [J] . Bielefeld Eric C. Hearing Research: An International Journal . 2013,第Null期

机译：Fischer 344 / NHsd大鼠顺铂引起的听力损失与年龄相关的听力损失模式
3. Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344/NHsd rats. [J] . Tanaka C, Bielefeld EC, Chen GD The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2009,第7期

机译：增强的声学环境对中年Fischer 344 / NHsd大鼠与年龄有关的听力损失的改善作用。
4. Multiplex iTRAQ-based Quantitative Approach for Cochlear Nucleus Proteomics in a Mouse Model of Age-Related Hearing Loss (AHL) [C] . Harsha P. Gunawardena, Ling Xie, Yanbao Yu, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：基于多路复用ITRAQ的耳蜗核蛋白质组学在年龄相关听力损失（AHL）模型中的耳蜗蛋白质组学的定量方法（AHL）
5. Age-related loss of gamma-aminobutyric acid in the central nucleus of the inferior colliculus in Fischer-344 rats: A possible neurochemical substrate for central presbycusis. [D] . Raza, Ahmad. 1991

机译：Fischer-344大鼠下丘脑中央核中与年龄相关的γ-氨基丁酸的损失：中枢性老花眼的可能神经化学底物。
6. Age-related hearing loss in the Fischer 344/NHsd rat substrain [O] . Eric C. Bielefeld, Donald Coling, Guang-Di Chen, -1

机译：Fischer 344 / NHsd大鼠亚菌株的年龄相关性听力损失
7. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat [O] . Eric C Bielefeld, Donald Coling, Guang-Di Chen, 2008

机译：乙酰左旋肉碱（ALCAR）的多种给药策略无法改变Fischer 344 / NHsd大鼠与年龄有关的听力损失

Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat

摘要

著录项

引文网络

相似文献

相关主题

期刊订阅