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Dehydrocostus lactone inhibits in vitro gastrinoma cancer cell growth through apoptosis induction sub-G1 cell cycle arrest DNA damage and loss of mitochondrial membrane potential

机译：脱氢肋骨内酯通过凋亡诱导亚G1细胞周期阻滞DNA损伤和线粒体膜电位丧失来抑制体外胃泌素瘤癌细胞的生长

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摘要

IntroductionThe purpose of the present study was to evaluate the antiproliferative activity of dehydrocostus lactone against human BON-1 cancer cell lines and to explore the possible underlying mechanism.

机译：引言本研究的目的是评估脱氢肋内酯对人BON-1癌细胞的抗增殖活性并探讨可能的潜在机制。

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期刊名称 Archives of Medical Science : AMS
作者
Hou-yong Long; Qing-xian Huang; Yong-yang Yu; Zhen-bin Zhang; Zeng-wu Yao; Hong-bing Chen; Jun-wei Feng;
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作者单位

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年(卷),期 2019(15),3
年度 2019
页码 765–773
总页数 9
原文格式 PDF
正文语种
中图分类基础医学;
关键词
dehydrocostus lactone pancreatic neuroendocrine tumor cell cycle apoptosis;

机译：肋前突脱水内酯;胰腺神经内分泌肿瘤;细胞周期;细胞凋亡;

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1. Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion [J] . Wu Hui-Juan, Wu Hong-Bo, Zhao Yan-Qiu, Oncology reports . 2016,第1期

机译：从佛手柑中分离的佛手柑通过诱导细胞凋亡，细胞周期停滞，线粒体膜电位丧失以及抑制细胞迁移和侵袭，在肺腺癌中发挥体内和体外抗肿瘤活性。
2. Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells [J] . Zeqi Wu, Xintong Xu, Lingjie Dai, The Journal of toxicological sciences . 2020,第1期

机译：eUpalinolide J诱导人前列腺癌细胞中的细胞凋亡，细胞周期骤停，线粒体膜潜在的破坏和DNA损伤
3. Polyphenol-rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines, and induces cell cycle arrest at the G(0)/G(1)-phase, apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells [J] . Zhao Quan, Huo Xue-Chen, Sun Fu-Dong, Molecular medicine reports . 2015,第4aPta1期

机译：丹参中富含多酚的提取物在不同的癌细胞系中均表现出抗癌活性，并诱导胰腺癌细胞在G（0）/ G（1）期的细胞周期停滞，凋亡和线粒体膜电位的丧失。
4. Effects of Electric Pulses on Cancer Cells: Apoptosis Induction and Decrease of Mitochondrial Transmembrane Potential [C] . Xiao Deyou, Tang Liling, Jiang Fangyi, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

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5. Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes [D] . Han, Jing Y. 2009

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6. Polyphenol-rich extract of Salvia chinensis exhibits anticancer activity in different cancer cell lines and induces cell cycle arrest at the G0/G1-phase apoptosis and loss of mitochondrial membrane potential in pancreatic cancer cells [O] . QUAN ZHAO, XUE-CHEN HUO, FU-DONG SUN, -1

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7. Antitumor effects of iridomyrmecin in HeLa cervical cancer cells are mediated via apoptosis induction, loss of mitochondrial membrane potential, cell cycle arrest and down-regulation of PI3K/Akt and up-regulation of lncRNA CCAT2 expression [O] . Li Lin, Xiao-Ling Cheng, Ming-Zhe Li, 2016

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8. Role of GADD34 (Growth Arrest and DNA Damage-Inducible Protein) in Regulating Apoptosis, Proliferation, and Protein Synthesis in Human Breast Cancer Cells [R] . Welser, D. C. 2005

机译：GaDD34（生长抑制和DNa损伤诱导蛋白）在调节人乳腺癌细胞凋亡，增殖和蛋白质合成中的作用

Dehydrocostus lactone inhibits in vitro gastrinoma cancer cell growth through apoptosis induction sub-G1 cell cycle arrest DNA damage and loss of mitochondrial membrane potential

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